1 edition of Lipid rafts in immunity found in the catalog.
Lipid rafts in immunity
|Statement||guest editor, Carrie Miceli.|
|Series||Seminars in immunology -- v. 13, issue 2.|
|Contributions||Miceli, M. Carrie, 1961-|
|The Physical Object|
|Pagination||p. 85-157 :|
|Number of Pages||157|
INTRODUCTION. Lipid rafts are plasma membrane microdomains that are implicated in the assembly of diverse signaling pathways such as those mediated by growth factors, morphogens, integrins (Simons, ), and antigen receptors on immune cells (Field, ; Xavier, ; Miceli, ; Cheng, a; Holowka, ).These domains are rich in glycosphingolipids and cholesterol, which together. The lipid raft association of PTEN induced by substitution of the cholesterol of the lipid rafts with ceramide was implicated in attenuation of the PI3K−Akt-mediated signal pathway [4,11], indicating that inducing complex formation of p85α with PTEN in the lipid rafts could be a good strategy for blocking PI3K-driven oncogenic : Tsung-Lin Lee, Shyang-Guang Wang, Wen-Ling Chan, Ching-Hsiao Lee, Tian-Shung Wu, Meng-Liang Lin, Shi.
Lipid rafts are highly ordered membrane microdomains enriched in cholesterol, glycosphingolipids, and certain proteins. They are involved in the regulation of cellular processes in diverse cell types, including mast cells (MCs). The MC lipid raft protein composition was assessed using qualitative mass spectrometric characterization of the proteome from detergent-resistant membrane fractions Cited by: 1. S. L. Veatch*, Electroformation and Fluorescence Microscopy of Giant Vesicles with coexisting liquid phases Lipid Rafts in Methods in Molecular Biology Ed T. McIntosh, Humana Press, Totowa, NJ () Book Chapter; S. L. Veatch and S. L. Keller*, Seeing Spots: Complex Phase Behavior in Simple Membranes Biochim. Biophys.
Alfalah et al., ). Scaffolding proteins associate with the lipid rafts and facilitate the trafficking of raft-embedded brush border enzymes. For example, annexin II is responsible for the trafficking of sucrase and ezrin to brush border lipid rafts (Heinz et al., ). Ezrin is a member of the ezrin-. This book provides the most updated information of how membrane lipids mediate protein signaling from studies carried out in animal and plant cells. Also, there are some chapters that go beyond and expand these studies of protein-lipid interactions at the structural level. The book begins with a literature review from investigations associated.
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One key difference between lipid rafts and the plasma membranes from which they are derived is lipid composition. Research has shown that lipid rafts contain 3 to Lipid rafts in immunity book the amount of cholesterol found in the surrounding bilayer. Also, lipid rafts are enriched in sphingolipids such as sphingomyelin, which is typically elevated by 50% compared to the plasma membrane.
Chhanda Biswas, in Immunity and Inflammation in Health and Disease, Enhanced Aggregation of Lipid Rafts and TCR Activation in SLE T-cells. Lipid rafts are cholesterol-rich domains found on the cell surface, and normally aggregation of lipid rafts appears especially at the site of TCR-antigen ligation.
This ensures inception of optimal immunological synapse necessary for maximum T. Lipid rafts are microdomains of the plasma membrane enriched in cholesterol and sphingolipids, and play an important role in the initiation of many pharmacological agent-induced signaling pathways.
Lipid raft: | | | Lipid raft organisation, region (1) is standard lipid bil World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available. This review focuses on how membrane lipid rafts have been detected and isolated, mostly from lymphocytes, and their associated proteins identified.
These proteins include transmembrane antigens/receptors, GPI-anchored proteins, cytoskeletal proteins, Src-family protein kinases, G-proteins, and other proteins involved in signal by: Glycosphingolipid Ganglioside Innate immunity Acquired immunity Lipid rafts Pattern recognition receptor Intracellular pathogens This is a preview of subscription content, log in to check access.
Springer Nature is developing a new tool to find and evaluate by: 2. Coordination of Innate and Adaptive Immune Responses. The immune system is made up of 2 distinct arms—the innate and adaptive immune systems. Proper function and defense conferred by these systems depends on sophisticated developmental and maturation processes in lymphoid tissues, including the bone marrow, thymus, spleen, and lymph nodes (22, 23), and the intricate coordination Cited by: Isolation and Analysis of Detergent-resistant Lipid Rafts.
IgE-primed RBL-2H3 cells (40 × 10 6) were harvested from suspension culture dishes with mM EDTA in Hanks' buffered saline without divalent cells were resuspended in Hanks' buffered saline, divided into two aliquots, and held for 2 min at 37°C with or without DNP-BSA (1 μg/ml).Cited by: Innate Immunity,edited byJonathan Ewbank and Eric Vivier, Lipid Rafts,edited by Thomas J.
McIntosh, in this book have already provided detailed information on lipid rafts, and. The textbook that has defined the field of immunology since is now in its thoroughly revised and updated Sixth Edition. This comprehensive, up-to-date text will be of interest to graduate students,post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role/5(4).
The lipid rafts must direct these ships to their proper locations near the breach in the cell wall, at the papilla. Then, and only then, can the PLDδ be properly deployed to unleash the PA signal.
With this defense strategy, the plants win the battle, but will they win the war?Cited by: 1. Lipids are the main component of cellular membranes. They are highly diverse in structure, and the distribution of different lipids and their species (membrane lipid Cited by: Among many other things, this interferon signaling results in the production of a protein that disrupts cholesterol rich areas in the cell membrane called lipid rafts.
Many different types of viruses take advantage of lipid rafts in our cells as a point of entry, as well as exploiting them for other uses. 12 Production of this protein may. With lipid rafts, the concept was used several times in other parts of the book to understand such central ideas as endocytosis.
As a science, we continue to learn about significant medical application opportunities, such as a possible effective therapy for HIV infection and other viral conditions (for example, see New non-drug fix for HIV).
() - WASHINGTON (Feb. 10, ) – The human protein apolipoprotein A-I binding protein (AIBP) inhibits HIV replication by targeting lipid rafts and reducing virus-cell fusion, according to a new study published in the premier American Society for Microbiology journal mBio by researchers from the George Washington University.
ISBN: OCLC Number: Description: 1 online resource ( pages): illustrations (some color). Contents: LIPID RAFTS: PROPERTIES, CONTROVERSIES AND ROLES IN SIGNAL TRANSDUCTION; Library of Congress Cataloging-in-Publication Data; Contents; Preface; Chapter I: The Role of Glycosphingolipids in Lipid Rafts: Lessons from Knockout Mice.
Mechanisms of innate immunity against bacterial infection at a physical barrier such as the skin or mucosal surfaces. (1) Symbiotic or commensal bacteria residing on the skin occupy limiting attachment sites on the skin and consume limiting nutrients, making colonization by potentially pathogenic microorganisms unlikely.
(2) If pathogens do attach, the skin is an effective physical barrier and. Landing of immune receptors and signal proteins on lipid rafts: a safe way to be spatio-temporally coordinated.
Immunol. Lett. 82, 14 R. Zidovetzki, Y. Yarden, J. Schlessinger, T.M. Jovin. Rotational diffusion of epider mal growth factor complexed to cell surface receptors reflects rapid microaggregation and endocytosis of occupied.
Skip to Article Content; Skip to Article InformationCited by: Lipid raft microdomains were conceived as part of a mechanism for the intracellular trafficking of lipids and lipid-anchored proteins.
The raft hypothesis is based on the behavior of defined lipid mixtures in liposomes and other model membranes. Experiments in these well-characterized systems led to operational definitions for lipid rafts in cell membranes. These definitions, detergent Cited by:. Viruses are the most abundant infectious agents on earth and the most primitive form of life, predating us by billions of years.
Due to the fact that viruses utilize host cell machinery to replicate, the host has the daunting task of distinguishing virus infection signatures from self-molecules.
This chapter provides an overview of the mechanisms used to sense virus infection (innate Author: Akiko Iwasaki.Dr. Tamm received his basic training in Molecular Biosciences at the Biozentrum of the University of Basel, Switzerland. After one year at Cornell University, where he studied microtubules by electron crystallography as part of his Master’s thesis (), he joined the group of Joachim Seelig at the University of Basel to obtain his Ph.D.
degree [ ].Stacked in the lipid bilayer, cholesterol decreases a membrane’s fluidity and its permeability to neutral compounds, as well as protons and sodium ions. Cholesterol may play a role in signaling by helping with construction of lipid rafts within the cell membrane.
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